University of Oregon
Supporting Stations: ARSV Laurence M. Gould, Palmer Station
This project will study the adaptive evolution of degenerative bone loss over geological time in Antarctic icefish and how it mimics the maladaptive development of osteopenia over ontogenetic time in an aging human. Genes and gene pathways whose bone building activities or bone destruction activities changed during icefish evolution are likely related to those that are altered in activity in human bone loss diseases. Thus, the long-term goal of the project is to characterize the genetic and phenotypic differences between related species of Antarctic fish with osteopenic versus normal skeletons (icefish and rockcod, respectively) and thereby identify new candidate genes, new genetic pathways, and new potential mechanisms for human bone degeneration diseases.
Deploying Team Members:
Bill Detrich (Co-PI)
John Postlethwait (PI)