2012-2013 Science Planning Summaries
U.S. Antarctic Program - Science Support Section United States Antarctic Program United States Antarctic Program Logo National Science Foundation Logo
 
Developmental Mechanisms for the Evolution of Bone Loss
 

Program Manager:
Dr. Diana Nemergut

B-029-L/P

ASC POC/Implementer:
Addie Coyac / Philip Spindler / Robert Kluckhohn

Dr. John Harvey Postlethwait (Principal Investigator)
jpostle@uoneuro.uoregon.edu

University of Oregon
Eugene, Oregon

Supporting Stations:  ARSV Laurence M. Gould, Palmer Station
Research Locations:  

Project Description:
This project will study the adaptive evolution of degenerative bone loss over geological time in Antarctic icefish and how it mimics the maladaptive development of osteopenia over ontogenetic time in an aging human. Genes and gene pathways whose bone building activities or bone destruction activities changed during icefish evolution are likely related to those that are altered in activity in human bone loss diseases. Thus, the long-term goal of the project is to characterize the genetic and phenotypic differences between related species of Antarctic fish with osteopenic versus normal skeletons (icefish and rockcod, respectively) and thereby identify new candidate genes, new genetic pathways, and new potential mechanisms for human bone degeneration diseases.

Deploying Team Members:

  • Bill Detrich (Co-PI)
  • Urjeet Khanwalkar
  • John Postlethwait (PI)
  • Eileen Sheehan

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Curator: Esther L. Hill PhD, Antarctic Support Contract   |   NSF Official: Alexandra Isern, Division of Polar Programs